{"id":11070,"date":"2011-06-22T12:00:00","date_gmt":"2011-06-22T03:00:00","guid":{"rendered":"https:\/\/www.tsukuba-sci.com\/cms\/?p=11070"},"modified":"2011-06-22T12:00:00","modified_gmt":"2011-06-22T03:00:00","slug":"%e5%ae%89%e5%85%a8%e6%80%a7%e9%ab%98%e3%81%84ips%e7%b4%b0%e8%83%9e%e3%82%92%e5%8a%b9%e7%8e%87%e8%89%af%e3%81%8f%e4%bd%9c%e8%a3%bd%ef%bc%9a%e7%94%a3%e6%a5%ad%e6%8a%80%e8%a1%93%e7%b7%8f%e5%90%88","status":"publish","type":"post","link":"https:\/\/www.tsukuba-sci.com\/cms\/?p=11070","title":{"rendered":"\u5b89\u5168\u6027\u9ad8\u3044iPS\u7d30\u80de\u3092\u52b9\u7387\u826f\u304f\u4f5c\u88fd
\uff1a\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240\/ \u4eac\u90fd\u5927\u5b66\/\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\/\u65b0\u30a8\u30cd\u30eb\u30ae\u30fc\u30fb\u7523\u696d\u6280\u8853\u7dcf\u5408\u958b\u767a\u6a5f\u69cb\u306a\u3069"},"content":{"rendered":"

\u3000(\u72ec)\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240\u306f6\u67089\u65e5\u3001\u4eac\u90fd\u5927\u5b66iPS\u7d30\u80de\u7814\u7a76\u6240\u3084(\u72ec)\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\u3001(\u72ec)\u65b0\u30a8\u30cd\u30eb\u30ae\u30fc\u30fb\u7523\u696d\u6280\u8853\u7dcf\u5408\u958b\u767a\u6a5f\u69cb\u306a\u3069\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u53d7\u7cbe\u5375\u306a\u3069\u306e\u5375\u7d30\u80de\u3067\u5f37\u304f\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u300cGlis1(\u30b0\u30ea\u30b91)\u300d\u3092\u7528\u3044\u308b\u3068\u3001\u5f93\u6765\u306e\u65b9\u6cd5\u306b\u6bd4\u8f03\u3057\u3066\u975e\u5e38\u306b\u52b9\u7387\u826f\u304fiPS\u7d30\u80de(\u4e07\u80fd\u7d30\u80de)\u3092\u4f5c\u88fd\u3067\u304d\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3068\u767a\u8868\u3057\u305f\u3002
\u3000iPS\u7d30\u80de\u306f\u3001\u4f53\u306e\u3042\u3089\u3086\u308b\u7d44\u7e54\u7d30\u80de\u306b\u5206\u5316\u3059\u308b\u80fd\u529b\u3092\u6301\u3064\u591a\u80fd\u6027\u5e79\u7d30\u80de\u3067\u3001\u76ae\u819a\u306a\u3069\u306e\u4f53\u7d30\u80de\u306b4\u3064\u306e\u907a\u4f1d\u5b50(Oct3\/4\u3001Sox\u3001Kif4\u3001c-Myc)\u3092\u5c0e\u5165\u3057\u3066\u4f5c\u308b\u3002\u4eac\u90fd\u5927\u5b66\u306e\u5c71\u4e2d\u4f38\u5f25\u6559\u6388\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u30012006\u5e74\u306b\u4e16\u754c\u3067\u521d\u3081\u3066\u30de\u30a6\u30b9\u7d30\u80de\u3067\u4f5c\u88fd\u3057\u3001\u7fcc\u5e74\u306b\u30d2\u30c8\u7d30\u80de\u3067\u4f5c\u88fd\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f\u3002
\u3000\u3057\u304b\u3057\u3001\u3053\u3046\u3057\u3066\u4f5c\u88fd\u3055\u308c\u305fiPS\u7d30\u80de\u306f\u3001\u5c0e\u5165\u3057\u305f\u907a\u4f1d\u5b50c-Myc\u306e\u5f71\u97ff\u306b\u3088\u3063\u3066\u816b\u760d(\u304c\u3093)\u306e\u767a\u751f\u304c\u5fc3\u914d\u3055\u308c\u3066\u3044\u305f\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001c-Myc\u306a\u3057\u3067\u306f\u3001iPS\u7d30\u80de\u306e\u4f5c\u88fd\u52b9\u7387\u304c\u6975\u7aef\u306b\u4f4e\u3044\u3053\u3068\u3082\u3042\u3063\u3066\u3001\u5b89\u5168\u306aiPS\u7d30\u80de\u3092\u52b9\u7387\u3088\u304f\u4f5c\u308b\u65b9\u6cd5\u306e\u958b\u767a\u304c\u5f37\u304f\u671b\u307e\u308c\u3066\u3044\u305f\u3002
\u3000\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u81e8\u5e8a\u5fdc\u7528\u306b\u4f7f\u7528\u3067\u304d\u308biPS\u7d30\u80de\u306e\u52b9\u7387\u306e\u826f\u3044\u4f5c\u88fd\u65b9\u6cd5\u3092\u78ba\u7acb\u3059\u308b\u305f\u3081\u3001\u3088\u308a\u5b89\u5168\u3067\u3088\u308a\u52b9\u7387\u306e\u9ad8\u3044\u65b0\u3057\u3044\u907a\u4f1d\u5b50\u3092\u63a2\u7d22\u3057\u3066\u304d\u305f\u3002\u305d\u306e\u904e\u7a0b\u3067\u3001\u7523\u7dcf\u7814\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u3082\u3068\u306b1,437\u500b\u306e\u907a\u4f1d\u5b50\u306e\u4e2d\u304b\u3089\u3001Glis1\u3092\u63a2\u3057\u3042\u3066\u305f\u3002
\u3000\u4eca\u56de\u3001\u304c\u3093\u3068\u306e\u95a2\u9023\u304c\u6307\u6458\u3055\u308c\u305fc-Myc\u306e\u4ee3\u308f\u308a\u306bGlis1\u3092\u4f7f\u3044\u30013\u3064\u306e\u907a\u4f1d\u5b50(Oct3\/4\u3001Sox\u3001Kif4)\u3068\u5171\u306b\u3001\u30d2\u30c8\u3084\u30de\u30a6\u30b9\u306e\u7dda\u7dad\u82bd\u7d30\u80de(\u76ae\u819a\u306a\u3069\u304b\u3089\u5f97\u3089\u308c\u308b\u7d30\u80de\u306e\u4e00\u7a2e)\u306b\u5c0e\u5165\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001c-Myc\u3092\u542b\u3080\u5f93\u6765\u306e4\u907a\u4f1d\u5b50\u3092\u4f7f\u7528\u3059\u308b\u65b9\u6cd5\u306b\u6bd4\u3079iPS\u7d30\u80de\u3092\u4f5c\u88fd\u3059\u308b\u52b9\u7387\u304c\u5927\u5e45\u306b\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001Glis1\u306f\u3001iPS\u7d30\u80de\u306b\u306a\u308c\u306a\u3044\u4e0d\u5b8c\u5168\u306a\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u5236\u3057\u3001\u5b8c\u5168\u306biPS\u7d30\u80de\u306b\u306a\u3063\u305f\u7d30\u80de\u306e\u307f\u3092\u5897\u6b96\u3055\u305b\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u307e\u305f\u3001Glis1\u304ciPS\u7d30\u80de\u306e\u4f5c\u88fd\u3092\u4fc3\u9032\u3059\u308b\u6a5f\u69cb(\u4ed5\u7d44\u307f)\u306b\u3064\u3044\u3066\u3082\u8a73\u7d30\u306a\u89e3\u6790\u3092\u884c\u3063\u305f\u3002
\u3000\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306f\u3001Glis1\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5b89\u5168\u6027\u306e\u9ad8\u3044iPS\u7d30\u80de\u3092\u52b9\u7387\u3088\u304f\u4f5c\u88fd\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u81e8\u5e8a\u5fdc\u7528\u306b\u4f7f\u7528\u3067\u304d\u308biPS\u7d30\u80de\u4f5c\u88fd\u65b9\u6cd5\u306e\u78ba\u7acb\u306b\u5927\u304d\u304f\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002
\u3000\u3053\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u82f1\u56fd\u306e\u79d1\u5b66\u8a8c\u300cNature\u300d6\u67089\u65e5\u53f7\u306b\u63b2\u8f09\u3055\u308c\u305f\u3002<\/p>\n

\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3000(\u72ec)\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240\u306f6\u67089\u65e5\u3001\u4eac\u90fd\u5927\u5b66iPS\u7d30\u80de\u7814\u7a76\u6240\u3084(\u72ec)\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\u3001(\u72ec)\u65b0\u30a8\u30cd\u30eb\u30ae\u30fc\u30fb\u7523\u696d\u6280\u8853\u7dcf\u5408\u958b\u767a\u6a5f\u69cb\u306a\u3069\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u53d7\u7cbe\u5375\u306a\u3069\u306e\u5375\u7d30\u80de\u3067\u5f37\u304f\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u300cGlis1(\u30b0\u30ea\u30b91)\u300d\u3092\u7528\u3044\u308b … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-11070","post","type-post","status-publish","format-standard","hentry","category-topics"],"_links":{"self":[{"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=\/wp\/v2\/posts\/11070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11070"}],"version-history":[{"count":0,"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=\/wp\/v2\/posts\/11070\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tsukuba-sci.com\/cms\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}